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ea0063gp165 | Obesity (1) | ECE2019

Role of invasive and non-invasive diagnostic tests in differential diagnosis of ACTH-dependent Cushing’s syndrome

Barbot Mattia , Ferrante Emanuele , Ceccato Filippo , Daniele Andrea , Lizzul Laura , Cuman Margherita , Monteleone Valerio , Serban Andreea , Sala Elisa , Locatelli Marco , Arosio Maura , Boscaro Marco , Scaroni Carla , Mantovani Giovanna

Background: Differential diagnosis of ACTH-dependent hypercortisolism is crucial to indicate a proper treatment and is based on CRH-, high-dose dexamethasone suppression-test (HDDST) and pituitary MRI. However, up to 50% of cases of Cushings disease (CD) present a negative MRI or a visible lesion < 6 mm. In these patients, guidelines suggest to perform bilateral inferior petrosal sinus sampling (BIPSS) in order to establish a correct diagnosis. Aim of this study was ...

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ea0099rc8.2 | Rapid Communications 8: Thyroid | Part II | ECE2024

Somatic RAS mutations in thyroid nodules: possible protective effect?

Verrienti Martina , Lupo Sabrina , De Cao Giacomo , Franceschetti Paola , Crociara Anna , Daniele Andrea , Bruni Stefania , Ambrosio Maria Rosaria , Zatelli Maria Chiara

Introduction: Thyroid nodules (TN) may display somatic RAS mutations, that, however, lack of diagnostic value. In our experience, somatic RAS mutation evaluation could be useful since it has a very high negative predictive value. In the past, somatic RAS mutation had been associated with a good prognosis in thyroid cancer.Objective: This study aims to evaluate whether somatic RAS mutation may associate with TN differential growth pattern.<p class="ab...

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Endocrine Abstracts

Role of invasive and non-invasive diagnostic tests in differential diagnosis of ACTH-dependent Cushing’s syndrome

Somatic RAS mutations in thyroid nodules: possible protective effect?

BiosciAbstracts